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KMID : 0043319950180040277
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Archives of Pharmacal Research
1995 Volume.18 No. 4 p.277 ~ p.281
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Synthesis of 4-Hydroxycoumarion Derivatives-1: An Efficient Synthesis of Flocoumafen
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Park Oee-Sook
Jang Bong-Suek
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Abstract
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An anticoagulant, 4-hydroxy-3-[1, 2, 3, 4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyll-1 -naphthyl]coumarin (Flocoumafen) was synthesized in 8 steps starting from phenylacetyl shloride and anisole. The key step in the synthesis involves the reaction of 3-(4-methoxyphenyl)-1-teralol with 4-hydroxycoumarin to give 4-hydroxy-3 [1, 2, 3, 4-tetrahydro-3-[4-emthoxyphenyl]-1-naphthyl]coumarin.
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KEYWORD
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4-Hydroxy-3-[1, 2, 3, 4-tetrahydro-3-{4-(4-trifluoromethylbenzyloxy)phenyl}-1-naph-thyl]coumarin (Flocoumafen), Anticoagulant, Rodenticide, Phenylacetyl chloride, Anisole
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